My goal is to understand the role of mismatch repair (MMR) in maintaining genome stability in the yeast Saccharomyces cerevisiae. In organisms ranging from E. coli to humans, DNA MMR plays an important role in preventing spontaneous point mutations. MMR also plays an important role in preventing recombination between divergent DNA sequences. These activities are of great interest to plant geneticists who are attempting to disrupt genes via homologous recombination and to human geneticists who are studying correlations between defects in MMR genes and familial forms of colon cancer.
We developed web-based tools for teaching microscopy to students in our course.
Our research uses comparisons of genomic variability within and between species of insects, mammals, and plants to provide novel insights into biological function and mechanisms of genetic change.
The Weill Institute for Cell and Molecular Biology (WICMB) at Cornell is an interdisciplinary center that conducts basic research to further our understanding of the workings of the human cell. This research project in the WICMB focuses on the regulation and roles of cellular membrane trafficking pathways in cell design and function.
We are developing information and methodologies that can be used broadly to understand and manipulate gene expression in a wide array of organisms. This information is not only crucial to understanding critical stages in cell and organismal regulation, but it is fundamentally important in understanding and treating disease, as well as in the control of genes that influence agricultural production and resistance to disease.
Conversion of cellulose is key for the production of biofuels of second and third generation. The project aims to understand the fundamental mechanisms of enzymatic conversion of model and real lignocellulosic subtrates.
Small Steps are Easier Together (SS) was a pilot environmental intervention in small rural worksites in Upstate New York in collaboration with Cornell Cooperative Extension educators. Leaders at worksites teamed with co-workers to choose and implement worksite changes to promote walking and healthy eating.
Identification was performed for the New York State Department of Agriculture and Markets survey program of pests that may pose a threat to agriculture in New York. The lab examined 261 trap samples for 11 targets in 2008.
This Biology Journal Club is intended for Biology undergraduates who wish to become familiar with the scientific literature in modern biology by learning to read, analyze, understand, and present summaries of original research papers in biology.
I am developing a new, quantitative, optical microscopy technique providing high resolution, high accuracy, phase, amplitude and polarization images of transparent, unstained, biological specimens. In conjunction with existing methods of quantitative fluorescence microscopy, it will lead to fully digital/computational multi-modal optical microscopy and significantly advance the capabilities of current optical methods.