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It`s no surprise that severely diseased grapes make poor wine. However, we found that even trace levels of powdery mildew set in motion a sequence of events that results in severely downgraded and wine that could not be sold. The damage is not due to the powdery mildew itself, but to how it shifts the naturally occurring (and normally beneficial) microbial community on grape berries towards one that produces foul flavors and odors during winemaking.